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KMID : 0613820100200121792
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Journal of Life Science
2010 Volume.20 No. 12 p.1792 ~ p.1800
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Structure Determination of Macrolactin Compounds with Antibacterial Activities Isolated from Bacillus polyfermenticus KJS-2
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Kim Dong-Hee
Kang Kyung-Ran
Kim Hyun-Woo
Yoon Si-Yeol
Kim Chun-Gyu
Tokutaro Yamaguchi
Sohng Jae-Kyung
Kang Jae-Seon
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Abstract
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In this study, we isolated five macrolactin compounds from a fermentation broth of Bacillus polyfermenticus KJS-2. The macrolactin compounds were structurally identified as macrolactin A (MA), 7-O-malonyl macrolactin A (MMA), 7-O-succinyl macrolactin A (SMA), macrolactin E (ME) and macrolactin F (MF) via a variety of NMR techniques, COZY, DEPT, HMQC and HMBC, and mass and specific rotation assays. The three macrolactin compounds, MA, MMA and SMA, profoundly inhibited the growth of both vancomycin-resistant Enterococci (VREs) and methicillin-resistant Staphylococcus aureus (MRSA), the inhibition of which were estimated via a disc agar diffusion bioassay. MA, MMA, and SMA exhibited antibacterial activities superior to those of vancomycin and teicoplanin.
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KEYWORD
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Bacillus polyfermenticus KJS-2, macrolactin, antibacterial activity, vancomycin-resistant Enterococcus, methicillin-resistant Staphylococcus aureus
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